If you’re facing a similar experience, know that you’re not alone. Here are some brain-based ways to boost mood that I recommend to patients who are trying to feel better during this uncertain time. Whenever you have a sad, hopeless, or worthless thought, your brain releases chemicals that make you feel bad. On the flip side, hopeful, loving, happy thoughts release chemicals that make you feel good. While you’re sheltering at home, if most of your thoughts are focused on what you hate about self-isolation, your brain and body will be drowning in feel-bad chemicals. To trigger the release of those feel-good neurochemicals while you’re practicing social distancing, you have to proactively search out the silver linings of self-isolation. Here are some questions to ask yourself: Each of these natural remedies may help aid your mood, but if you’re experiencing prolonged symptoms of depression, consider reaching out to a medical professional. If you or someone you love is experiencing suicidal depression, please contact the National Suicide Prevention Lifeline at 1-800-273-8255.